N-cadherin: stabilizing synapses
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چکیده
منابع مشابه
N-cadherin: stabilizing synapses
Spines are sites of excitatory synapse formation in central neurons. Alterations in spine structure and function are widely believed to actively contribute to the cellular mechanisms of learning and memory. In this issue, Mendez et al. (2010. J. Cell Biol. doi:10.1083/jcb.201003007) demonstrate a pivotal role for the cell adhesion molecule N-cadherin in activity-mediated spine stabilization, of...
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n page 465, Ireton et al. report an unexpected mechanism by which cells can increase E-cadherin levels to boost their stickiness. Their findings stem from an unusual cell line that allows a direct analysis of the function of a cadherin modulator. E-cadherin is the main cell–cell adhesion molecule in epithelial tissues. Down-regulation of E-cadherin occurs in many carcinoma types and correlates ...
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ISSN: 1538-4101 (Print) 1551-4005 (Online) Journal homepage: http://www.tandfonline.com/loi/kccy20 N-cadherin: A new player in neuronal polarity Annette Gärtner, Eugenio F. Fornasiero & Carlos G. Dotti To cite this article: Annette Gärtner, Eugenio F. Fornasiero & Carlos G. Dotti (2012) N-cadherin: A new player in neuronal polarity, Cell Cycle, 11:12, 2223-2224, DOI: 10.4161/cc.20797 To link to...
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Cadherin interactions ensure the correct registry and anchorage of cells during tissue formation. Along the plasma membrane, cadherins form inter-junctional lattices via cis- and trans-dimerization. While structural studies have provided models for cadherin interactions, the molecular nature of cadherin binding in vivo remains unexplored. We undertook a multi-disciplinary approach combining liv...
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N-Cadherin has an important role during dendrite arborization, axon guidance, and synaptogenesis. In particular, at synaptic sites, N-cadherin is involved in the regulation of cell-cell adhesion and in morphology and plasticity control. Recent studies have shown that N-cadherin can be cleaved by the metalloproteinase ADAM10. Here we demonstrate that impairing ADAM10 localization and activity at...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2010
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.201004022